Journal details
Effects of haematinics and vitamin B-complex on growth and physio-biochemical parameters in mice

Published Date: 30 Dec 2016

Keywords: Haematinics, vitamin B-complex, growth, physiology, mice

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Amjad Hossen1 and Md. Royhan Gofur2* 1Department of Physiology, Bangladesh Agricultural University, Bangladesh 2Department of Veterinary and Animal Sciences, University of Rajshahi, Bangladesh

Abastract:

Context: Haematinics and vitamin B-complex provide crucial benefits from promoting sound health to preventing diseases. Objectives: The study was conducted to investigate the effects of vitamin B-complex and haematinics on growth (body weight gain) and physiobiochemical parameters in animals (mice model). Materials and Methods: We used mice as animal model and considered body weight gain as an indicator of growth. A total of fifteen adult (7 weeks old) male Swiss albino mice were randomly assigned into three equal groups. Group A was considered as control group provided with normal rat pellets. Group B was supplemented with copper sulphate and ferrous sulphate solution @ 0.5ml/mice at every alternative day orally and group C with vitamin B-complex (B-50 FORTE® Injection) @ 0.1ml/mice/week intramuscularly along with rat pellets for 30 days. Results: The mean body weight of vitamin B-complex and haematinic treated groups were significantly (p<0.01) higher compared to control group. Total erythrocyte and leukocyte counts were significantly (p<0.05) higher in group B and C compared to control group A. Hemoglobin concentration was also increased significantly (p<0.01) in all treated mice. A significant increase (p<0.01) in the packed cell volume concentration was recorded in group B but it was slightly increased in group C compared to control one. The concentration of serum glutamic pyruvic transaminase decreased significantly (p<0.01) in both group B and C. The cholesterol and uric acid values were insignificantly decreased in both treated groups. Conclusion: Haematinics and vitamin B-complex may be used to get best results in improving the growth (body weight gain), blood profiles and liver functions without any detrimental effect in animals